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KMID : 0367419940370101386
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Journal of Korean Pediatric Society
1994 Volume.37 No. 10 p.1386 ~ p.1396
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Studies on the B Cell Proliferation and Differentiation Factors in Human B Cell System
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Abstract
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We have studied the function of lymphokines on human tonsillar B cell prolifertion and differentiation. B cells were stimulated with Staphylococcus aureus Cowanl (SAC) or anti- bead.
@ES The followings showed the results of this study.
@EN 1) In B cell activation, SAC induced B cell DNA synthesis but anti-μbead did not. SAC could activate and proliferate B cells. Minimal number of B cells were required to proliferate effectively.
2) In B cell proliferation, SAC could proliferate B cell in the abscence of lymphokines. Exogenous IL-2 or IL-4 enhanced B cell proliferation. The roles of IL-2 were very important in B cell proliferation. The effect of IL-4 on the IL-2 induced
B
cell
proliferation was inhibitory in SAC-B cells. IL-4 could enhance the proliferation of anti-μ bead activated B cells.
3) In B cell differentiation, IL-2 was a major factor to differentiate SAC activated B cells, but IL-4 did not. IL-6 had a synergistic effect on the differentiation.
The results of this study showed that the different signal transduction mechanisms were involved in B cell proliferation and differentiation. The B cell resposes to lymphokine were different, and it is depend upon antigens or mitogens.
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